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The MHRA and EMA do not list blood clots as a recognised adverse effect of GLP-1 agonists

This dual mechanism enhances glucosedependent insulin secretion while suppressing glucagon release, slowing gastric emptying, and promoting satiety through central appetite regulation [2]

A: Most benefits come from reduced appetite and better adherence to a calorie deficit

The 2025 GLP-1 guidelines have positioned these drugs at the forefront of type 2 diabetes management, reflecting their multifaceted benefits

Brand-name semaglutide showed roughly 14.9% mean weight reduction in the STEP-1 trial at 2.4 mg weekly over 68 weeks (Wilding et al., 2021)

Access this chapter Subscribe and save Buy Now Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others Abbreviations ASD: autism spectrum disorder BDNF: Brain-Derived Neurotrophic Factor C1q: complement component 1q C3: complement component 3 Ca 2+ : calcium CaMKII: calcium/calmodulin-dependent kinase II CASK: calcium/calmodulin-dependent serine protein kinase Cbln1: cerebellin 1 precursor protein Cl: chloride CNS: central nervous system CR3: complement receptor 3 E/I: excitatory/inhibitory ECM: extracellular matrix FGF: fibroblast growth factor FMRP: Fragile X Mental Retardation Protein GABA: gamma-aminobutyric acid GluR2: glutamate receptor-like molecule 2 LGN: Lateral Geniculate Nucleus MAGUK: Membrane-associated Guanylate Kinase MEF2c: myocyte enhancer factor 2c MEGF10: multiple EGF-like domains 10 mRNA: messenger RNA Munc13: Mammalian Homolog of Unc13 MuSK: Muscle specific kinase Na+: sodium NCAM: neural cell adhesion molecule NMDA: N-methyl-D-aspartate NMJ: neuromuscular junction Pcdh10: protocadherin 10 PSD: postsynaptic density PSD-95: postsynaptic density protein-95 RGCs: retinal ganglion cells RIM-BPs: RIM-Binding Proteins RIMs: Rab3A-Interacting Molecules SM: Sec1/Munc18-like SNARE: SNAP receptor TREM2: triggering receptor expressed on myeloid cells 2 TSP2: thrombospondin-2 References Ressot C, Bruzzone R